The mission of the Commission, which is defined in the Compact, is to enhance public welfare through comprehensive planning, water supply allocation, and management of the water resources of the Susquehanna River Basin.

To accomplish this mission, the Commission works to: reduce damages caused by floods; provide for the reasonable and sustained development and use of surface and ground water for municipal, agricultural, recreational, commercial and industrial purposes; protect and restore fisheries, wetlands and aquatic habitat; protect water quality and instream uses; and ensure future availability of flows to the Chesapeake Bay.

The Mine Drainage program involves assessment and planning initiatives that lead to design and construction of abandoned mine drainage (AMD) treatment systems and abandoned mine land (AML) restoration projects throughout the Basin.